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. 2020 Nov 17;10:19940. doi: 10.1038/s41598-020-76518-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Manhattan type plot showing the significance of association (p-value) between 1,410 UK Biobank traits and brain age difference, coloured by trait category. The Bonferroni-corrected significance threshold is marked by a horizontal red line (p-value = 2.35 × 10^–5) and the 5% FDR correction threshold with a blue line (p-value = 1.45 × 10^–3). More details on significant traits is found in Table 1. Trait label 1: Time taken to start entering values in symbol-digit matching test, 2: Number of symbol digit matches made correctly, 3: Number of symbol digit matches attempted, 4: Multiple sclerosis, 5: Essential (primary) hypertension, 6: Diagnoses—secondary ICD10: Type 1 diabetes, 7: Type 2 diabetes, 8: Systolic brachial blood pressure during pulse wave analysis (PWA), 9: Central systolic blood pressure during PWA, 10: Cardiac index during PWA, 11: End systolic pressure during PWA, 12: Stroke volume during PWA, 13: Central augmentation pressure during PWA, 14: Cardiac output during PWA, 15: Central pulse pressure during PWA, 16: Peripheral pulse pressure during PWA, 17: Ventricular rate, 18: Diastolic blood pressure, 19: Body mass index (BMI), 20: Hand grip strength (left), 21: Hand grip strength (right), 22: Systolic blood pressure, 23: Taking insulin, 24: Number of treatments/medications taken.