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Equilibrium dissociation constant (KD) values.
| MCPH1TBM | KD (μM) |
|---|---|
| WT | 0.24 ± 0.10 |
| Y330A | N.D. |
| Y330E | N.D. |
| L332A | N.D. |
| S333A | 0.16 ± 0.02 |
| S333D | 21 ± 4 |
| S333E | 14 ± 1 |
| S333PHOS | 79 ± 23 |
| P334A | 24 ± 4 |
KD values, calculated from ITC data, for binding of MCPH1TBM and several MCPH1TBM mutant peptides with TRF2TRFH. ND: not detected.
