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. 2020 Nov 17;11:5843. doi: 10.1038/s41467-020-19702-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — (a–d) Heatmaps of the normalized ATAC-seq intensities (z-scores) of peaks enriched in normal, unaffected and affected CD4 (CD4⁺ T cells) (a), CD8 (CD8⁺ T cells) (b), DC (dendritic cells) (c) and Fib (fibroblasts) (d). Cluster 1-6 represents the peak groups enriched in normal only, normal and unaffected, unaffected only, unaffected and affected, affected only, and normal and affected cells respectively. Each row is a peak and each column is a sample. Source data are provided as a Source Data file. (e–h) Ratios of peaks in each cluster compare with total number of significant differential peaks in CD4 (e), CD8 (f), DC (g), and Fib (h). (i) Enrichment of known transcription factor (TF) motifs in DCs isolated from healthy donors, and unaffected and affected skins from SSc patients. Source data are provided as a Source Data file. (j) Comparison of aggregate footprints for NFκB and STAT1 in DCs isolated from normal, unaffected or affected skins.