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. 2020 Nov 17;11:5843. doi: 10.1038/s41467-020-19702-z

Fig. 5. Conventional dendritic cells were more infiltrated in affected compare with normal skin.

Fig. 5

(a) Immunohistochemistry analysis of ZBTB46 expression in normal and affected skin from SSc patient. 12 normal skin samples and 8 affected skin samples were included in our experiments. (b) Average expression of ZBTB46 protein in normal (n = 12) and affected (n = 8) skin from SSc patient. P value was estimated by one-sided Mann–Whitney U test. The upper, centre, and lower line indicates 75% quantile +1.5 * interquartile range (IQR), 50% quantile and 25% quantile −1.5 * IQR respectively. Source data are provided as a Source Data file. (c) The expression of cDC (conventional dendritic cells) marker gene ZBTB46 in normal (n = 33, 34, 36) and SSc (n = 58, 99, 61) skin in three published datasets. P value was estimated by one-sided Mann–Whitney U test. The upper, centre, and lower line of the box indicates 75%, 50%, and 25% quantile, respectively. The upper and lower whisker of the boxplot indicates 75% quantile +1.5 * interquartile range (IQR) and 25% quantile −1.5 * IQR. Source data are provided as a Source Data file.