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. 2020 Nov 17;10:19997. doi: 10.1038/s41598-020-77095-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Pharmacokinetics analysis of TRAIL, TRAIL-ATNC, and TRAIL-ATNC^IL4rP. Proteins were injected into mice using retro orbital injection (n = 3 for each protein). (A–C) Relative serum concentrations of native TRAIL (A), TRAIL-ATNC (B), and TRAIL-ATNC^IL4rP (C) were evaluated at periodic intervals by western blotting with an antibody against human TRAIL (Protein, estimated total amount of each proteins; Control serum, serum derived from the untreated mice). The quantification of the amount of TRAIL proteins present in each sample was done using Image J program. (D–F) Estimated half-lives (T_1/2) of TRAIL (D), TRAIL-ATNC (E), and TRAIL-ATNC^IL4rP (F) were calculated using GraphPad Prism v7.0. Error bars represent ± SEM.