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. 2020 Nov 17;10:19997. doi: 10.1038/s41598-020-77095-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-tumor effect of the TRAIL-ATNC^IL4rP in MDA-MB-231 tumor bearing mice. (A) Schematic diagram of MDA-MB-231 xenograft model experiment. MDA-MB-231 cells were injected subcutaneously to right flank of nude mice. After tumor volumes reached ~ 100 mm³, mice were treated with TRAIL-ATNC^IL4rP (10 mg/kg, n = 6), GFP-Ferritin (10 mg/kg, n = 7), TRAIL (5 mg/kg, equivalent to the number of moles of TRAIL in a dose of TRAIL-ATNC^IL4rP, n = 7), or saline, pH 7.4 (control, n = 5) eight times every 2 or 3 d via intravenous injection. (B) Tumor growth rate in mice treated with the TRAIL-ATNC^IL4rP, TRAIL, GFP-Ferritin, and saline. (C) Weights of excised tumors from each group at 21 d post-injection. Data represent means ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001; T-test) (B,C). (D) Kaplan–Meier survival curves after start of treatment. (E) Representative images of apoptotic cells, which were determined using TUNEL assays, in tumor sections from mice treated with TRAIL-ATNC^IL4rP, TRAIL, GFP-Ferritin, or saline (control) (Scale bars: 30 µm). (F) The body weight change of each group during anti-tumor therapy.