Table 1.

Binding kinetics of TRAIL-ATNC and TRAIL against TRAIL receptor DR5.

Ligand	kon (M−1 S−1)a	koff (S−1)a	KD (M)b
TRAIL-ATNC	(3.77 ± 0.24) × 105	(9.15 ± 9.14) × 10–5	(2.56 ± 2.58) × 10–10
TRAIL	(2.58 ± 0.60) × 104	(1.50 ± 0.38) × 10–3	(6.02 ± 1.99) × 10–8

^aObtained by saturated binding responses at least three independent runs of SPR measurements.

^bK_D = k_off/k_on.