Table 3.
Biological pathway enrichment in bovine ffEV proteins via the analysis of functional protein association networks.
| # Term ID | KEGG pathways description | N proteins (ffEVs) | N proteins (background) | FDR |
|---|---|---|---|---|
| bta03010 | Ribosome | 46 | 138 | 3.65e−41 |
| MRPL3,RPL10,RPL10L,RPL11,RPL13,RPL14,RPL15,RPL18,RPL18A,RPL19,RPL21,RPL23,RPL23A,RPL26RPL27,RPL27A,RPL30,RPL32,RPL35,RPL35A,RPL38, RPL4,RPL5,RPL6,RPL7,RPL7A,RPL8,RPLP0,RPS10,RPS11,RPS13,RPS14,RPS17,RPS18,RPS2,RPS23,RPS24,RPS27A,RPS3, RPS3A,RPS4Y1,RPS5,RPS7,RPS8, RPS9,RPSA | ||||
| bta04141 | Protein processing in endoplasmic reticulum | 26 | 160 | 4.12e−16 |
| CALR,CANX,CKAP4,DAD1,DDOST,ERP29,GANAB,HSP90AA1,HSP90AB1,HSP90B1,HSPA5,HSPA6,HSPA8,LMAN1,LMAN2,PDIA3,PDIA4,PDIA6,PRKCSH, RPN1,RPN2,SEC24C,SEC61A1,SSR4,UGGT1,VCP | ||||
| bta04145 | Phagosome | 23 | 155 | 1.43e−13 |
| ATP6V0D1,ATP6V1E1,C3,CALR,CANX,CGN1,DYNC1I2,IGHM,ITGA2,ITGAV,ITGB1,ITGB3,LAMP2,M6PR,MRC2,RAB7A,RAC1,SEC22B,SEC61A1,STX7, TFRC,TUBA1C,TUBB2A | ||||
| bta04610 | Complement and coagulation cascades | 17 | 82 | 4.38e−12 |
| A2M,C1QB,C3,C4A,C5,C8G,C9,CFH,CFI,CLU,F2,FGA,FGB,FGG,PLG,SERPIND1,VTN | ||||
| bta04979 | Cholesterol metabolism | 8 | 46 | 3.86e−05 |
| APOA1,APOA4,APOE,LRPAP1,SORT1,VDAC1,VDAC2,VDAC3 | ||||
| bta04216 | Ferroptosis | 7 | 40 | 0.00013 |
| CP,FTL,PCBP1,TF,TFRC,VDAC2,VDAC3 | ||||
| bta04918 | Thyroid hormone synthesis | 8 | 70 | 0.00043 |
| ALB,ATP1A1,CANX,GPX8,HSP90B1,HSPA5,PDIA4,TTR | ||||
| bta04721 | Synaptic vesicle cycle | 7 | 59 | 0.0010 |
| AP2A1,AP2B1,ATP6V0D1,ATP6V1E1,CLTA,CLTC,NAPA | ||||
| bta03040 | Spliceosome | 9 | 125 | 0.0028 |
| HNRNPA3,HNRNPU,HSPA6,HSPA8,PCBP1,SFRS13A,SRSF7,SRSF9,TRA2B | ||||
| bta04612 | Antigen processing and presentation | 7 | 76 | 0.0032 |
| CALR,CANX,HSP90AA1,HSP90AB1,HSPA6,HSPA8,PDIA3 | ||||
| bta03050 | Proteasome | 5 | 45 | 0.0090 |
| PSMA1,PSMA5,PSMA6,PSMC6,PSMD2 | ||||
| bta04810 | Regulation of actin cytoskeleton | 10 | 192 | 0.0090 |
| F2,GSN,ITGA2,ITGA6,ITGAV,ITGB1,ITGB3,MYL12A,PFN2,RAC1 | ||||
| bta01200 | Carbon metabolism | 7 | 108 | 0.0142 |
| ADPGK,GAPDH,GOT2,MDH2,PGD,PGK1,PRPS1L1 | ||||
| bta04142 | Lysosome | 7 | 116 | 0.0183 |
| ATP6V0D1,CLTA,CLTC,CTSD,LAMP2,M6PR,SORT1 | ||||
| bta04144 | Endocytosis | 10 | 231 | 0.0208 |
| AP2A1,AP2B1,ARF1,CLTA,CLTC,HSPA6,HSPA8,RAB11A,RAB7A,TFRC | ||||
| bta04151 | PI3K-Akt signaling pathway | 13 | 352 | 0.0208 |
| COL6A1,HSP90AA1,HSP90AB1,HSP90B1,IGHM,ITGA2,ITGA6,ITGAV,ITGB1,ITGB3,RAC1,VTN,YWHAQ | ||||
| bta04217 | Necroptosis | 7 | 152 | 0.0498 |
| FTL,H2AFV,HSP90AA1,HSP90AB1,VDAC1,VDAC2,VDAC3 | ||||