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. 2020 Nov 4;11:591885. doi: 10.3389/fimmu.2020.591885

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Copyright © 2020 Campos, Preciado-Llanes, Azar, Kim, Brandon, López-Camacho, Reyes-Sandoval and Rossi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ChAdOx1 May but not ChAdOx1 Chik provides some cross-protection against foot swelling. (A) Foot thickness (in mm) at the Mayaro virus (MAYV) injection site. Data represented as mean and SEM, restricted maximum likelihood mixed model with Dunnett’s (compared with MAYV-IRES group). (B) Comparison between control foot (in grey) and the maximum foot thickness (in pink) at any given timepoint following MAYV injection. Dots represent each mouse, two-way ANOVA with Sidak’s. (C) Data represented as mean and SEM, restricted maximum likelihood mixed model with Dunnett’s (compared with PBS group). (D) Comparison between control foot (in grey) and the maximum footpad thickness (in pink) at any given timepoint following CHIKV injection. Dots represent each mouse, two-way ANOVA with Sidak’s. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. ns, not significant.