Table 1.
Survival of A129 mice challenged with Mayaro virus (MAYV) or chikungunya virus (CHIKV).
| Vaccine | Challenge | Number of mice in cohort | % Survival (number) | MDD1 | p-value2 |
|---|---|---|---|---|---|
| PBS | MAYV | 6 | 0% (0/6) | 3 +/− 0 | N/A |
| ChAdOx1 Zika | MAYV | 5 | 0% (0/5) | 3.6 +/− 0.5 | 0.0339 |
| MAYV-IRES | MAYV | 5 | 100% (5/5) | N/A | 0.0016 |
| ChAdOx1 May | MAYV | 5 | 100% (5/5) | N/A | 0.0016 |
| ChAdOx1 Chik | MAYV | 5 | 60% (3/5) | 9.5 +/− 3.5 | 0.0016 |
| PBS | CHIKV | 4 | 0% (0/4) | 4.4 +/− 0.5 | N/A |
| ChAdOx1 Zika | CHIKV | 5 | 0% (0/5) | 4.4 +/− 0.5 | 0.1763 |
| ChAdOx1 Chik | CHIKV | 5 | 100% (5/5) | N/A | 0.0047 |
| ChAdOx1 May | CHIKV | 5 | 80% (4/5) | 9 +/- 0 | 0.0047 |
1Mean Day of Death (MDD) +/− standard deviation. Excludes mice that survived.
2p-value, based upon Log-ranked (Mantel-Cox) test compared with PBS.