TABLE 1.

Differentially regulated genes involved in oxidative resistance and reactive oxygen species metabolism after performing PCR array analysis.

Gene	Description	Fold change
		Exp 1 (passage 7)	Exp 2 (passage 11)
DHCR24	24-Dehydrocholesterol Reductase	4.77	2.84
SIRT2	Sirtuin 2	4.76	1.88
TXNRD1	Thioredoxin Reductase 1	4.73	2.88
HMOX1	Heme Oxygenase 1	4.64	3.47
UCP2	Uncoupling Protein 2	2.43	2.88
PNKP	Polynucleotide Kinase 3’-Phosphatase	2.41	2.88
NQO1	NAD(P)H Quinone Dehydrogenase 1	2.40	2.42
PTGS2	Prostaglandin-Endoperoxide Synthase 2	2.40	1.42
SQSTM1	Sequestosome 1	2.39	1.71
GPX3	Glutathione Peroxidase 3	2.39	2.13
HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	2.38	2.28
RNF7	Ring Finger Protein 7	2.38	1.48
GSTP1	Glutathione S-Transferase Pi 1	2.38	2.80
GCLM	Glutamate-Cysteine Ligase Modifier Subunit	2.38	2.55
TXN	Thioredoxin	2.38	2.38
FTH1	Ferritin Heavy Chain 1	2.38	2.21
GSTZ1	Glutathione S-Transferase Zeta 1	2.37	2.81
PRDX5	Peroxiredoxin 5	2.37	2.81
SRXN1	Sulfiredoxin 1	2.37	1.40
GSS	Glutathione Synthetase	2.37	1.91
CCS	C-C Motif Chemokine Receptor 5	2.37	2.83
FOXM1	Forkhead Box M1	2.36	11.23
PRDX4	Peroxiredoxin 4	2.35	2.85
SOD3	Extracallular superoxide dismutaze [Cu-Zn]	2.30	2.86
TXNRD2	Thioredoxin Reductase 2	2.30	2.86
COL1A1	Collagen 1 A 1	2.10	1.81
GPX1	Glutathione peroxidase 1	1.45	1.53
NOS2	Nitric Oxide Synthase 2	−2.94	−2.55
LPO	Lactoperoxidase	−2.97	−2.30
NOX5	NADPH Oxidase 5	−3.23	−2.71
EPX	Eosinophil Peroxidase	−3.04	−2.58
DUOX2	Dual Oxidase 2	−3.10	−2.93
APOE	Apolipoprotein E	−3.26	−1.24
SEPP1	Selenoprotein P	−3.54	−1.26

The fold change threshold was set to ±2 to define significant increases or decreases in gene expression (indicated in bold). Analysis was performed in two passages (experiments 1 and 2).