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. 2020 Nov 4;7:592759. doi: 10.3389/fmed.2020.592759

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Copyright © 2020 Yan, Yao, Lu, Shao, Sun, Li and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The alpha and beta diversities between the demodex blepharitis patients and healthy controls. The Chao1 (A), Simpson (B), and Shannon index (C) representing the alpha diversity. The principal coordinate analysis was constructed using the Bray-Curtis method (E). Modified OSDI scores of patients with and without demodex blepharitis. The modified OSDI scores of the demodex blepharitis patients were significantly higher than those of the healthy controls (^**p < 0.05) (D). The multi-samples refraction curves. Steep slopes of the rarefaction curves of individual samples (F).