Table 4.
Univariate and multivariate analyses of demographic and clinicopathological prognostic factors for recurrence-free survival in 488 patients with BCLC stage B hepatocellular carcinoma (HCC), January 2007 to December 2015.
| Characteristics | Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|---|
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | ||
| Type of treatment | LR vs TACE+LR | 1.44 (1.17–1.76) | 0.001 | 1.55 (1.26–1.91) | <0.001 |
| Age, years | >60 vs. ≤60 | 0.97 (0.75–1.25) | 0.80 | – | – |
| Sex | Male vs. female | 0.85 (0.60–1.20) | 0.85 | – | – |
| Largest HCC tumor diameter, cm | ≥10 vs. < 10 | 1.51 (1.21–1.88) | <0.001 | 1.39 (1.11–1.75) | 0.005 |
| HCC tumors, n | >3 vs. ≤3 | 3.43 (2.73–4.32) | <0.001 | 2.98 (2.35–3.79) | <0.001 |
| Portal hypertensiona | Yes vs. no | 1.00 (0.66–1.53) | 0.99 | – | – |
| Alpha-fetoprotein (AFP), ng/mL | >400 vs. ≤400 | 1.35 (1.10–1.65) | 0.004 | NS | 0.12 |
| Type of hepatectomyb | Non-anatomical vs. anatomical | 1.31 (1.05–1.64) | 0.02 | NS | 0.09 |
| Resection marginc, cm | >1 vs. ≤1 | 0.97 (0.74–1.27) | 0.83 | – | – |
| Tumor encapsulationd | Yes vs. no | 0.86 (0.70–1.07) | 0.18 | – | – |
| Microscopic vascular Invasione |
Yes vs. no | 1.79 (1.45–2.21) | <0.001 | 1.45 (1.16–1.81) | 0.001 |
| Cirrhosise | Yes vs. no | 1.91 (1.55–2.36) | <0.001 | 1.74 (1.41–2.15) | <0.001 |
| Intraoperative blood transfusion | Yes vs. no | 0.92 (0.74–1.27) | 0.83 | – | – |
aPortal hypertension defined preoperatively as esophageal varices and/or splenomegaly on imaging studies combined with a decreased platelet count [100 × 103/μL or less]).
bDetermined by surgeon intraoperatively, anatomical approach based on the Brisbane 2000 nomenclature of liver anatomy, whereas non-anatomical approach consisted of wedge or limited resection.
cBased on intraoperative surgeon estimation.
dBased on intraoperative surgeon description of tumor appearing encapsulated or infiltrating (not encapsulated).
eBased on postoperative histopathology report.
BCLC, Barcelona Clinic Liver Cancer; CI, confidence interval; TACE, transarterial chemoembolization; LR, liver resection (hepatectomy); NS, not significant.
Bold values provided in this table was that P value < 0.05, there was significant difference between the two groups.