Table 1.

Applications of ROS-scavenging nanomaterials to treat periodontitis.

Nanomaterials	Polymers	Research mode	Quantitaive information	Advantages	References
Drug-loaded nanoparticles
Coenzyme Q10-loaded nanomicelles	Kolliphor® P 407	In vitro and in vivo	GI values decreased from 2.04 to 0.88, PI decreased from 2.06 to 0.80, and PPD also shallowed by about 41%	Improved drug stability and significantly ameliorate periodontal parameters	Shaheen et al., 2020
Biopolymer-silica composites loaded with L. divaricata Cav. extract	Chi and CMC	In vitro	The degree of incorporation of the extract for Chi-CMC-SiO2 composites was 44.36%	Presented a high activity of simil SOD and capacity to eliminate free radicals	Alvarez Echazú et al., 2018
ROS-responsive nanoparticles
Novel redox injectable gel	PMNT-PEG-PMNT triblock copolymer	In vitro and in vivo	The degree of bone loss of Pg and RIG@Pg rats was 0.479 ± 0.038 and 0.341 ± 0.035 mm, respectively	Recovered gingival blood flow and inhibited alveolar bone loss	Saita et al., 2016
Polydopamine nanoparticles	Polydopamine	In vitro and in vivo	PDA NPs with a dosage of 0.2 mg/site can decrease ROS-related fluorescence intensity	Exhibited biodegradable and admirable anti-inflammatory activity	Bao et al., 2018

Chi, Chitosan; CMC, carboxymethylcellulose; PMNT-PEG-PMNT, poly[4-(2,2,6,6-tetramethylpieridine-N-oxyl)aminomethylsyrene]-b-poly(-ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene]; GI, gingival index; PI, plaque index; PPD, periodontal pocket depth; Pg, porphyromonas gingivalis.