Table 1.
Nanomaterials | Polymers | Research mode | Quantitaive information | Advantages | References |
---|---|---|---|---|---|
Drug-loaded nanoparticles | |||||
Coenzyme Q10-loaded nanomicelles | Kolliphor® P 407 | In vitro and in vivo | GI values decreased from 2.04 to 0.88, PI decreased from 2.06 to 0.80, and PPD also shallowed by about 41% | Improved drug stability and significantly ameliorate periodontal parameters | Shaheen et al., 2020 |
Biopolymer-silica composites loaded with L. divaricata Cav. extract | Chi and CMC | In vitro | The degree of incorporation of the extract for Chi-CMC-SiO2 composites was 44.36% | Presented a high activity of simil SOD and capacity to eliminate free radicals | Alvarez Echazú et al., 2018 |
ROS-responsive nanoparticles | |||||
Novel redox injectable gel | PMNT-PEG-PMNT triblock copolymer | In vitro and in vivo | The degree of bone loss of Pg and RIG@Pg rats was 0.479 ± 0.038 and 0.341 ± 0.035 mm, respectively | Recovered gingival blood flow and inhibited alveolar bone loss | Saita et al., 2016 |
Polydopamine nanoparticles | Polydopamine | In vitro and in vivo | PDA NPs with a dosage of 0.2 mg/site can decrease ROS-related fluorescence intensity | Exhibited biodegradable and admirable anti-inflammatory activity | Bao et al., 2018 |
Chi, Chitosan; CMC, carboxymethylcellulose; PMNT-PEG-PMNT, poly[4-(2,2,6,6-tetramethylpieridine-N-oxyl)aminomethylsyrene]-b-poly(-ethylene glycol)-b-poly[4-(2,2,6,6-tetramethylpiperidine-N-oxyl)aminomethylstyrene]; GI, gingival index; PI, plaque index; PPD, periodontal pocket depth; Pg, porphyromonas gingivalis.