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. 2020 Nov 4;11:528308. doi: 10.3389/fphar.2020.528308

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Copyright © 2020 Zhang, Liu, Li, Zhao, Zhang, Wei, Ran, Jin and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic effects of RPL on A549 cells (A) and HUVEC cells (B). Cells were treated with RPL (0, 0.75, 1.5, 3.0, 6.0, 12, and 24 µg/mL) for 24 h. Finally, CCK-8 assays were carried out to detect the cytotoxic effects of candidate drugs. The IC₅₀ values were calculated for evauation of the cytotoxic effects of candidate drugs.