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. 2020 Nov 12;24:100852. doi: 10.1016/j.bbrep.2020.100852

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© 2020 Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — H&E stained sections of liver from a negative control rat (Group I) showing intact normal hepatic architecture (X100) (A). DEN/CCL₄ -treated rats (Group II) showed mild portal mononuclear inflammatory infiltrate and marked macrosteatotic changes of the hepatocytes (X400) (B), markedly dysplastic hepatocytes with karyomegaly and prominent macronucleoli (X400) (C). Group III rats demonstrated almost normal hepatic architecture (X400) (D), while group IV rats showed minimal portal inflammatory infiltrate (X100) (E). Administration of PSP for 14 weeks (Group V) (X400) (F), or for the last 4 weeks of the experiment (Group VI) showed almost normal morphology (X100) (G).