Figure 2.

Lymph Fluid Flow Profiles Were Estimated in Quiescent and Remodeled LNs

To model the affect of lymphatic remodeling or inflammation on the ability of a circulating cell to adhere to SCS-lining cells (A), a simplified geometric model of an afferent lymphatic vessel leading into the LN SCS (B) was imported into COMSOL to perform fluid flow simulations quantifying the wall shear stress (WSS) profile along the SCS floor (solid line) (C). This COMSOL-generated WSS estimation was in close agreement to the analytical solution for WSS profiles in a radial flow chamber (dashed line).

(D–G) The analytically calculated ranges of WSS levels for (D, F) human or (E, G) mouse LNs based on maximum and minimum literature cited parameters (Table 1) for (D, E) volumetric flow rate or (F, G) SCS height.

(H and I) COMSOL shear stress simulation plots along the (H) floor of the subcapsular sinus or (I) Z-plane of the radial flow chamber LN model.