Figure 5.

Co-presentation of Adhesion Molecules Alters the WSS Dependency of LS174T Cell Adhesion in Flow

The number (A and C) and average rolling velocity (B) of LS174T cells adhering to E-selectin alone or when co-presented with ICAM or VCAM in flow regimes modeled after a quiescent LN (top row), LN with a dilated LVD (middle row), or LN with a dilated SCS (bottom row). Data are represented as mean ± SEM. ∗, #, and $ indicate significance (p<0.05) by two-way ANOVA with Tukey's post-hoc test, between E-selectin and E-selectin + 2.5 μg/mL VCAM, E-selectin and E-selectin + 10μg/mL VCAM, and E-selectin and E-selectin + 2.5μg/mL ICAM, respectively.