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. 2020 Oct 31;23(11):101751. doi: 10.1016/j.isci.2020.101751

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Flow Microenvironment and Adhesive Molecule Presentation Impact Cumulative Extent of Cell Adhesion along Channel Length

(A–D) Influence of LN SCS-mimicking flow regime during flow across E-selectin (A), E-selectin + ICAM (B), E-selectin + 2.5 ug/mL VCAM (C), and E-selectin + 10 ug/mL (D).

(E–G) Influence of adhesive molecule presentation in microfluidics modeling the quiescent LN (E), dilated LVD (F), and dilated SCS (G). Data are represented as mean ± SEM. ∗ (p<0.05), ∗∗ (p<0.01), ∗∗∗ (p<0.001), and ∗∗∗∗ (p<0.0001) indicate significance by one-way ANOVA with Tukey's post-hoc test.