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. 2020 Nov 12;6(11):e05442. doi: 10.1016/j.heliyon.2020.e05442

Figure 2.

Figure 2

Apoptotic cell death in cisplatin sensitive, resistant and supra resistant ovarian cancer cells. A) Annexin V/PI staining was performed for the detection of early and late apoptosis by flow cytometry after 24 h of cisplatin treatment. Images and graphs are the representative of three independent experiments and data were expressed as Mean ± SD. (i) A2780 and A2780-Cp cells were treated with 5 μM CDDP and (ii) SKOV3 and SKOV3-Cp cells were treated with 10 μM CDDP. ∗P < 0.05 and ∗∗P < 0.01, control versus cisplatin treatment. B) Cell cycle analysis of cisplatin sensitive, resistant and supra resistant ovarian cancer cells. PI staining was performed for the detection of sub-G1 cells by flow cytometry. (i) A2780 and A2780-Cp cells and (ii) SKOV3 and SKOV3-Cp cells. ∗P < 0.05 and ∗∗P < 0.01, control versus cisplatin treatment.