Table 2.
Calculation of shift in case mix distribution for early diagnosed SLE
| Disease status | ||||
|---|---|---|---|---|
| Mild | Moderate | Severe | Total | |
| Assume severity mix for SDLT from Garris (19) a | ||||
| No. | 789 | 1558 | 643 | 2990 |
| % | 26.39 | 52.11 | 21.51 | 100 |
| Use Oglesby (10) to calculate change in patients with early vs. late SLE diagnosis b | ||||
| Early SLE diagnosis | 2703 | 1161 | 302 | 4166 |
| Late SLE diagnosis | 2305 | 1465 | 396 | 4166 |
| No. of individuals displaced (early – late SLE) | 398 | −304 | −94 | NA |
| % of total (4166) displaced | 9.55 | −7.30 | −2.26 | NA |
| Shift Garris (19) based on displacement percentages c | ||||
| Calculation | 789 + (2990 × 9.55%) | 1,558 + (2990 × −7.30%) | 643 + (2990 × −2.26%) | 2990 |
| New total | 1074.65 | 1339.81 | 575.53 | 2990 |
| Severity mix for early diagnosis, % | 35.94 | 44.81 | 19.25 | 100.00 |
Abbreviations: SDLT, standard diagnostic laboratory test; SLE, systemic lupus erythematosus.
a
Displays the SLE severity mix from Garris (19), which is used for late‐diagnosed SLE in the model.
b
Case distribution mix for early‐ vs late‐diagnosed SLE from Oglesby (10). Using this table category, for each severity, the number displaced was calculated (early diagnosis – late diagnosis). The percent of total (4166) displaced for each severity was then determined.
c
This percentage of total displaced was then applied to the Garris (19) case mixture values to shift severity distribution. The resulting case mix is used in the model for early‐diagnosed SLE.