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. 2020 Nov 18;8(4):484–492. doi: 10.1016/j.gendis.2020.11.005

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© 2020 Chongqing Medical University. Production and hosting by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Liver functions abnormality with cholangiocyte injury during hospitalization in the patients with SARS-CoV-2 and chronic HBV co-infection. 116 COVID-19 cases with negative serum HBsAg (SARS-CoV-2 group) and 17 inactive HBV carriers with COVID-19 (SARS-CoV-2 + HBV group) were enrolled in this study. Serum samples were collected during the 3 weeks after the onset of symptoms and tested in parallel for ALP (A–B) and GGT (C–D). The positive ratios of serum ALP (A) and GGT (C) outliers were calculated for each group. The mean values of serum ALP (B) and GGT (D) levels were analyzed and compared between the two groups, respectively. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ns, not significant. ALP, alkaline phosphatase; GGT, gamma-glutamyltransferase.