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RPA protects cytosines against deamination by A3A. A 30 nucleotide DNA oligomer was either untreated (lane 1) or successively treated with A3A and Ung, and then heated in the presence of NaOH (lane 2). Alternately, the DNA was bound with excess RPA and then subjected to A3A. The A3A was inactivated by heating and RPA was released from DNA by the addition of excess unlabeled oligomer and then treated with Ung and electrophoresed under denaturation conditions (lane 3).
