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. 2020 Oct 17;48(20):11380–11393. doi: 10.1093/nar/gkaa712

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© ? The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — deH3K4me3 promoters in TG sperm retain H3K4me3 enrichment in the pre-implantation embryo. (A) Venn diagram indicating overlap between promoters with H3K4me3 in sperm and promoters with H3K4me3 in the two-cell embryo (two-cell embryo dataset retrieved from Liu et al. GSE73952) (23). (B) Venn diagram indicating overlap between promoters with deH3K4me3 in TG sperm and promoters with H3K4me3 in the two-cell embryo. (C) Joyplots representing H3K4me3 enrichment (RPKM + 8) in the two-cell embryo, and on the paternal allele of the pronuclear stage 5 (PN5), early two-cell, late two-cell, four-cell, eight-cell pre-implantation embryos, ±1 kb TSS with deH3K4me3 in TG sperm (two-cell embryo dataset from Liu et al. GSE73952, paternal allele-specific pre-implantation embryo dataset from Zhang et al. GSE71434. See methods for description of re-analysis of Zhang et al.) (25). Integrative Genome Viewer tracks of (D) the Bbip1 and (E) the Wdr47 promoters that have deH3K4me3 in TG sperm, H3K4me3 enrichment in total two-cell embryo, as well as H3K4me3 enrichment on the paternal allele of PN5 to 8-cell embryo.