Figure 4.
The DNA sequences methylated by the Bacteroides fragilis MTases. (A) The methylated sequences in the genome of B. fragilis NCTC9343. The methylated motifs identified by SMRT sequencing and corresponding R-M systems are placed together in single rectangles. The modified nucleotides are indicated with red characters. The genetic arrangements of the Bfa9343IV and Bfa9343V loci, the inverton-negative Type I R-M systems, are depicted; the sequences with uncertain MTase assignments are indicated with question marks. (B) The DNA motifs methylated by the hsdSA alleles. The sequence recognized by each of the eight hsdSA alleles is presented along with the identification of the pneumococcal strain used for the sequencing. R = A or G, Y = T or C, N = any four nucleotides.