Fig. 5.

(A, B) Western blot analyses of apoptosis-related protein expressions by WEP1 treatment in H22 transplanted tumors. The relative ratio was expressed as a relative expression (RE) value calculated from the ratio of target protein to β-actin or GAPDH protein. Data represented three independent experiments. *P < 0.05 and **P < 0.01 compared with negative control group. (C) Potential mechanism of actions of WEP1-regulated cell proliferation and apoptosis in H22-bearing mice through ROS-mediated mitochondrial pathway.