Figure 1.

Risk of all-cause dementia as a function of cardiovascular risk factors at all ages and during midlife. Hazard ratios were multifactorially adjusted for age (as time scale), APOE genotype, number of GWAS risk alleles, and the listed modifiable risk factors. Analyses in the lower three panels were restricted to individuals aged 40–60 years at baseline. P from Cox regression. P-values fulfilling a Bonferroni corrected criteria of 0.006 are marked with an *. For APOE genotype and number of GWAS risk alleles P was for trend. APOE, apolipoprotein E gene; APOE genotype, ε2/ε3/ε4 APOE genotype; CI, confidence interval; GWAS, genome-wide association study.