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. 2020 Nov 9;21(21):8394. doi: 10.3390/ijms21218394

Figure 2.

Figure 2

KLHL30 and KLHL38, little studied KLHL genes, have super-enhancer chromatin and DNA hypomethylation that can drive their high, muscle-specific expression. (A–D) KLHL30 (chr2:239,043,816-239,065,093) and (E–H) KLHL38 and its downstream neighbor, FBXO32 (chr8:124,508,193-124,686,846). Tracks from UCSC Genome Browser are as described in Figure 1. The immediate upstream neighbor of KLHL38, FBXO32/Atrogen-1, a gene encoding an E3-ubiquitin ligase, is implicated in muscle atrophy [37]. Boxed regions are tissue-specific epigenetic marks described in the text; triangles, sites where MyoD is bound.