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. 2020 Nov 9;21(21):8394. doi: 10.3390/ijms21218394

Figure 3.

Figure 3

Epigenetic profiles for KEAP1/KLHL19 and ENC1/KLHL37, which encode critical proteins that bind to NRF2 and regulate adaptation of cells to oxidative stress. (A–D) KEAP1 (chr19:10,591,087-10,619,523) and (B–H) ENC1 (chr5:73,908,815-73,950,517). Tracks are shown as in Figure 1. SkM 1 refers to psoas muscle while SkM 2 and SkM 3 are SkM from upper leg [4,15]. Boxed regions are tissue-specific epigenetic marks; orange and blue arrows are previously reported human phenotype-linked hypomethylated CpG sites described in the text. FC, frontal cortex; SG, salivary gland; PFC, prefrontal cortex; Hippoc, hippocampus; AG, angular gyrus; FG, frontal gyrus.