Figure 4.

Multiple segments of enhancer chromatin without brain-specific DNA hypomethylation are associated with highly preferential expression in brain of KLHL32 and KBTBD11. (A–D) KLHL32 (chr6:97,324,594-97,615,081) and (B–H) KBTBD11 (chr8:1,917,290-1,976,132). Tracks are as in Figure 1. The GTEx RNA-seq bar graphs are in linear scale but the scale for KBTBD11 is different from that of its 5′ overlapping antisense transcript RP11-439C15.4, as indicated by the TPM values for frontal cortex. The green highlighting in the DNA methylation tracks for KBTBD11 refers to a region with leukemia-subtype-related DNA hypomethylation as previously reported [52] and explained in Section 3. Boxed regions are tissue-specific epigenetic marks described in the text; PFC, prefrontal cortex; FC, frontal cortex; AC, anterior cortex; MFG, midfrontal gyrus; Hippoc, hippocampus.