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. 2020 Oct 28;21(21):8012. doi: 10.3390/ijms21218012

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mass spectrometric analysis of the proteome of CD4⁺ T cells from therapy-naïve patients with HIV and CD4⁺/HIV⁻ T cells. (a) Protein abundance in CD4⁺ T cells from therapy naïve-patients infected with HIV. Results are shown as a volcano plot. Protein abundance of three replicates is plotted as log2 value against the negative decadic logarithm of the p values. Proteins were regarded as regulated from factor 1.2 and p value < 0.05. Significantly upregulated proteins due to HIV infection are shown in red and downregulated proteins in green; (b) network analysis for up-and downregulated proteins are illustrated in green, not colored proteins were added by the IPA algorithm. High-confidence interactions are symbolized by a continuous line; medium-confidence interactions are symbolized by a dashed line.