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. 2020 Nov 6;21(21):8336. doi: 10.3390/ijms21218336

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Cordycepin reduced the expression of FGFR1-4 in FGF9-induced allograft model. (A) The immunohistochemical (IHC) assay of the expression patterns of FGFR1, FGFR2, FGFR3 and FGFR4 in MA-10 tumor tissues from Control/PBS, BSA/PBS, FGF9/PBS, FGF9/COR and Control/COR treated mice (original magnification 200×). (B–E) IHC quantification of the expression of (B) FGFR1, (C) FGFR2, (D) FGFR3 and (E) FGFR4 in MA-10 tumor tissue from (A). Quantification values are represented as the mean ± SEM, n = 5. p values were calculated using one-way ANOVA with Tukey’s multiple comparisons post-tests, ** p < 0.01, *** p < 0.001. COR: cordycepin.

Cordycepin reduced the expression of FGFR1-4 in FGF9-induced allograft model. (A) The immunohistochemical (IHC) assay of the expression patterns of FGFR1, FGFR2, FGFR3 and FGFR4 in MA-10 tumor tissues from Control/PBS, BSA/PBS, FGF9/PBS, FGF9/COR and Control/COR treated mice (original magnification 200×). (B–E) IHC quantification of the expression of (B) FGFR1, (C) FGFR2, (D) FGFR3 and (E) FGFR4 in MA-10 tumor tissue from (A). Quantification values are represented as the mean ± SEM, n = 5. p values were calculated using one-way ANOVA with Tukey’s multiple comparisons post-tests, ** p < 0.01, *** p < 0.001. COR: cordycepin.