Skip to main content
. Author manuscript; available in PMC: 2020 Nov 18.
Published in final edited form as: Clin Genet. 2015 Jul 20;89(4):434–441. doi: 10.1111/cge.12623

Fig. 1.

Fig. 1.

Clinical features of the patients. (a) Case 1. Absence of subcutaneous fat, muscular hypertrophy, marked umbilical prominence, large hands and feet, enlarged liver and spleen. (b, c) Case 3. Hypertrophy of skeletal muscles, enlarged liver and spleen. (d) Case 4. Mild generalized loss of subcutaneous fat and muscular stature, marked umbilical prominence. (e) Case 6. Acromegalic appearance, protruding abdomen, marked umbilical prominence, velvety thickening and hyperpigmentation of the skin around neck, in axillae and antecubital fossae (acanthosis nigricans).