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. 2019 Apr 25;55(6):349–365. doi: 10.1177/0018578719844699

Updated List of Light-Sensitive Oral Medications

Scott Perkins 1,✉, Adam Evans 2, Allison King 3
PMCID: PMC7672668  PMID: 33245715

Abstract

The Campbell University Drug Information Center supports health professionals by providing responses to drug-related inquiries. An inquiry was received by the Drug Information Center for a comprehensive list of oral solutions which should be protected from light. In investigating this request for information, a list of light-sensitive oral prescription drug products published in Hospital Pharmacy in 2009 was identified. This discovery highlighted the need for both an updated list and one which distinguished oral solid products and oral liquid products. The purpose of this project was to update the previously published list and to distinguish between oral solid and liquid dosage forms. The process of updating this list entailed several professional resources. A list of all oral products was obtained and then sorted to clearly identify which products were available in oral solid dosage form only, oral liquid dosage form only, and both dosage forms. Once delineated, the product labels for each medication were scoured for language indicating the product is light sensitive.

Keywords: drug stability, medication safety, formulary management/P & T, information systems and technology

The Campbell University Drug Information Center is a nationwide resource center which supports the health professionals’ community by answering requests. The center receives more than 200 requests monthly and recently fielded a request for a comprehensive list of oral liquid medications that are recommended to be protected from light. Through an extensive literature search, only a list concerning light-sensitive oral prescription drugs published in Hospital Pharmacy in 2009 was found, which highlighted the need for an updated and more comprehensive list.1 The purpose of this project was to update the previously published list and to distinguish between oral solid and liquid dosage forms.

A list of oral medications that require protection from light was generated by conducting two different searches and then cross-referencing the results against each product’s package insert. Searches were conducted on the DailyMed website,2 the official provider of product labels from the US Food and Drug Administration (FDA), and Lexicomp3 using the search terms “protect from light,” “light-resistant,” and “original container.” The updated list also delineated oral dosage product formulation (ie, tablet, capsule, solution, suspension). Package inserts for each product formulation were reviewed to confirm the need for protection from light for the specific dosage form cited. Table 1 represents a compilation of the data found and includes products for which the manufacturer recommends protection from light, dispensation in a light-resistant container, or dispensation in the original container.

Table 1.

Oral Medications Which Should Be Protected From Light.

Oral solid Oral liquid Specific dosage form Commentsa
Acebutolol4 X Capsule
Acetaminophen5 X Oral solution
Acetaminophen and codeine6 X Oral solution
Acetazolamide7 X Tablet Dispense in a light-resistant container
Acitretin8 X Capsule
Acrivastine/Pseudophedrine9 X Capsule
Acyclovir10 X Oral suspension
Albuterol11 X Tablet
Alectinib12 X Capsule
Alendronate/Cholecalciferol13 X Tablet
Alfuzosin14 X Tablet, extended-release
Allopurinol15 X Tablet
Alosetron16 X Tablet, film-coated
Alprazolam17 X X Oral solution
Amiloride/Hydrochlorothiazide18 X Tablet
Amiodarone19 X Tablet
Amitriptyline20 X Tablet, film-coated
Amitriptyline/Perphenazine21 X Tablet, film-coated
Amlodipine22 X Tablet
Amoxicillin23 X Capsule—Tablet, coated
Anagrelide24 X Capsule Dispense in a light-resistant container
Apalutamide25 X Tablet
Aripiprazole26 X Tablet Dispense in a light-resistant container
Atenolol27 X Tablet
Atenolol/Chlorthalidone28 X Tablet
Auranofin29 X Capsule Dispense in a light-resistant container
Avanafil30 X Tablet
Azathioprine31 X Tablet
Bedaquiline32 X Tablet Dispense in a light-resistant container
Benazepril33 X Tablet—Tablet, film-coated
Benazepril/Hydrochlorothiazide34 X Tablet
Benzonatate35 X Capsule
Bexarotene36 X Capsule, liquid-filled
Bromocriptine37 X Tablet—Capsule
Bumetanide38 X Tablet Dispense in a light-resistant container
Buprenorphine39 X Tablet, sublingual Dispense in a light-resistant container
Bupropion40 X Tablet, extended-release
Buspirone41 X Tablet
Butalbital/Acetaminophen/Caffeine42,43 X X Capsule
Butalbital/Aspirin/Caffeine44 X Tablet
Calcitriol45 X X Capsules, gelatin-coated—Oral solution
Carbamazepine46-48 X X Tablet, chewable—Tablet, extended-release—Oral suspension
Carbidopa/Levodopa49 X Tablet
Carbinoxamine50 X X Tablet—Oral solution, extended-release Dispense in a light-resistant container
Carvedilol51 X Tablet, film-coated
Cefditoren52 X Tablet, film-coated
Cefpodoxime53 X Tablet, film-coated
Cefprozil54 X X Tablet, film-coated—Oral suspension Dispense in a light-resistant container
Cephalexin55 X Capsule
Chlordiazepoxide56 X Capsule
Chloroquine57 X Tablet
Chlorothiazide58 X Tablet
Chlorpheniramine59 X Tablet
Chlorpromazine60 X Tablet
Chlorthalidone61 X Tablet
Cimetidine62,63 X X Tablet, film-coated—Oral solution (repackaged)
Ciprofloxacin64 X Tablet, film-coated Dispense in a light-resistant container
Clarithromycin65 X Tablet, film-coated, extended-release
Clomiphene66 X Tablet
Clonazepam67 X Tablet
Clonidine68 X Tablet
Clorazepate69 X Tablet
Clozapine70,71 X X Tablet, oral disintegrating—Oral suspension Tablet: Dispense in a light-resistant container
Codeine72 X Tablet Dispense in a light-resistant container
Cortisone73 X Tablet
Cromolyn74 X Oral solution, concentrate
Cyclobenzaprine75 X Tablet, film-coated
Cyclosporine76,77 X X Tablet, film-coated—Oral solution
Cyproheptadine78 X Oral syrup
Cysteamine79 X Capsule
Danazol80 X Capsule Dispense in a light-resistant container
Dantrolene81 X Capsule Dispense in a light-resistant container
Dapsone82 X Tablet
Darifenacin83 X Tablet, film-coated, extended-release
Deferiprone84 X Oral solution
Desloratadine85,86 X X Tablet, film-coated—Oral solution
Desmopressin87 X Tablet Dispense in a light-resistant container
Dexamethasone88 X Tablet Dispense in a light-resistant container
Dexmethylphenidate89 X Capsule, extended-release
Dextroamphetamine90 X Tablet
Dextroamphetamine/Amphetamine91 X Capsule, extended-release
Diatrizoate92 X Oral solution
Diazepam93 X X Tablet—Oral solution—Oral concentrate
Diazoxide94 X Oral suspension
Diclofenac95 X Tablet, film-coated
Dicyclomine96 X Tablet—Capsule
Digoxin97 X Oral solution
Diltiazem98 X Tablet, extended-release
Diphenhydramine99 X Oral solution
Dipyridamole100 X Tablet, film-coated Dispense in a light-resistant container
Docusate101 X Oral liquid
Dolasetron102 X Tablet, film-coated
Doxepin103 X Capsule
Doxycycline104,105 X X Capsule—Oral suspension
Enalapril106 X Tablet (repackaged)
Entecavir107 X Tablet, film-coated
Ergocalciferol108 X Capsule
Ergoloid109 X Tablet
Ergotamine110 X Tablet, sublingual
Erythromycin111 X Tablet
Esomeprazole112 X X Capsule, extended-release—Powder for oral suspension
Estazolam113 X Tablet Dispense in a light-resistant container
Estradiol114 X Tablet
Ethosuximide115,116 X X Capsule, liquid-filled—Oral solution
Ethotoin117 X Tablet Dispense in a light-resistant container
Etodolac118 X Capsule
Etoposide119 X Capsule Dispense in a light-resistant container
Everolimus120 X Tablet
Ezetimibe/Simvastatin121 X Tablet
Famotidine122,123 X X Tablet—Powder for oral suspension
Febuxostat124 X Tablet
Felbamate125 X Tablet Dispense in a light-resistant container
Felodipine126 X Tablet, film-coated, extended-release
Fenofibrate127 X Capsule
Fenoprofen128 X Tablet, film-coated
Ferrous sulfate129 X Oral elixir Dispense in a light-resistant container
Finasteride130 X Tablet
Flavoxate131 X Tablet, film-coated Dispense in a light-resistant container
Flecainide132 X Tablet Dispense in a light-resistant container
Flucytosine133 X Capsule Dispense in a light-resistant container
Fluoxetine134,135 X X Capsule—Tablet, film-coated—Oral solution
Fluphenazine136,137 X Oral elixir—Oral concentrate
Flurazepam138 X Capsule
Flurbiprofen139 X Tablet
Flutamide140 X Capsule Dispense in a light-resistant container
Fluvastatin141 X Capsule
Fluvoxamine142 X Capsule, extended-release Dispense in a light-resistant container
Folic acid143 X Tablet
Frovatriptan144 X Tablet, film-coated Dispense in a light-resistant container
Furosemide145,146 X X Tablet—Oral solution
Gemfibrozil147 X Tablet
Glipizide/Metformin148 X Tablet, film-coated Dispense in a light-resistant container
Glyburide/Metformin149 X Tablet Dispense in a light-resistant container
Glycopyrrolate150 X Tablet
Granisetron151 X Tablet
Griseofulvin152,153 X X Tablet, film-coated—Oral suspension Dispense in a light-resistant container
Guaifenesin154 X Oral solution
Guanfacine155 X Tablet, extended-release Dispense in a light-resistant container
Haloperidol156,157 X X Tablet—Oral solution
Hydralazine158 X Tablet
Hydrochlorothiazide159 X Capsule
Hydrochlorothiazide/Triamterene160 X Capsule
Hydrocodone/Acetaminophen161 X Tablet (repackaged)
Hydrocodone/Guaifenesin162,163 X Oral liquid—Oral solution Dispense in a light-resistant container
Hydrocodone/Homatropine164,165 X X Tablet—Oral syrup Dispense in a light-resistant container
Hydrocodone/Ibuprofen166 X Tablet
Hydrocortisone167,168 X Tablet—Oral solution
Hydromorphone169 X Tablet
Hydroxychloroquine170 X Tablet
Hydroxyzine171,172 X X Tablet, film-coated—Oral syrup
Hyoscyamine173,174 X Tablet, orally disintegrating—Tablet Dispense in a light-resistant container
Iloperidone175 X Tablet
Indomethacin176 X Capsule
Isoniazid177,178 X X Tablet—Oral solution
Isosorbide mononitrate179 X Tablet
Isosorbide dinitrate180 X Tablet, film-coated, extended-release
Isosorbide dinitrate/Hydralazine181 X Tablet, film-coated
Isotretinoin182 X Capsule, liquid-filled
Isradipine183 X Capsule Dispense in a light-resistant container
Itraconazole184 X Capsule
Ketoconazole185 X Tablet
Ketoprofen186 X Capsule, extended-release
Ketorolac187 X Tablet, film-coated
Labetalol188 X Tablet, film-coated
Lactulose189 X Oral solution Dispense in a light-resistant container
Lamotrigine190 X Tablet, film-coated, extended-release
Lansoprazole191 X Capsule, delayed-release
Leflunomide192 X Tablet
Lesinurad193 X Tablet, film-coated
Letermovir194 X Tablet, film-coated
Levetiracetam195 X X Tablet, film-coated—Oral solution
Levodopa/Carbidopa196,197 X X Tablet—Oral solution
Levofloxacin198 X Tablet Dispense in a light-resistant container
Levothyroxine199-202 X Tablet, capsules
Linezolid203,204 X X Tablet, film-coated—Powder for suspension
Liothyronine205 X Tablet
Lisdexamfetamine206 X Tablet—Tablet, chewable
Lisinopril/Hydrochlorothiazide207 X Tablet
Lorazepam208,209 X X Tablet—Oral concentrate
Losartan210 X Tablet, film-coated
Losartan/Hydrochlorothiazide211 X Tablet, film-coated
Lovastatin212 X Tablet
Lubiprostone213 X Capsules, gelatin-coated
Maprotiline214 X Tablet, film-coated
Meclizine215 X Tablet Dispense in a light-resistant container
Meclofenamate216 X Capsule
Megestrol217 X X Tablet Dispense in a light-resistant container
Melphalan218 X Tablet
Memantine/Donepezil219 X Capsule Dispense in a light-resistant container
Metaproterenol220,221 X X Tablet—Oral syrup
Metformin222 X Tablet—Tablet, extended-release
Methadone223,224 X X Tablet—Oral concentrate
Methamphetamine225 X Tablet
Methenamine226 X Tablet
Methocarbamol227 X Tablet Dispense in a light-resistant container
Methotrexate228 X Tablet
Methsuximide229 X Capsule
Methyclothiazide230 X Tablet
Methyldopa231 X Tablet
Methyldopa/Hydrochlorothiazide232 X Tablet
Methylergonovine233 X Tablet Dispense in a light-resistant container
Methylphenidate234 X Tablet—Tablet, extended-release
Methylprednisolone235 X Tablet
Metoclopramide236,237 X X Tablet—oral solution
Metolazone238 X Tablet
Metoprolol tartrate239 X Tablet
Metronidazole240 X Tablet, film-coated
Midodrine241 X Tablet
Minocycline242 X Tablet, film-coated
Mirtazapine243 X Tablet
Montelukast244 X Tablet, chewable—Tablet, film-coated
Morphine245 X Tablet, film-coated, extended-release
Morphine/Naltrexone246 X Capsule, extended-release Dispense in a light-resistant container
Mycophenolate247 X Tablet, film-coated
Nabumetone248 X Tablet Dispense in a light-resistant container
Nadolol249 X Tablet
Naldemedine250 X Tablet Dispense in a light-resistant container
Naproxen251,252 X X Tablet—Oral suspension
Nebivolol253 X Tablet Dispense in a light-resistant container
Nefazodone254 X Tablet Dispense in a light-resistant container
Nicardipine255 X Capsule Dispense in a light-resistant container
Nifedipine256 X Capsule
Nilutamide257 X Tablet
Nimodipine258,259 X X Capsule, liquid-filled—Oral solution
Nisoldipine260 X Tablet, film-coated
Nitrofurantoin261 X Oral suspension
Nitroglycerin262 X Tablet (repackaged) Dispense in original container
Nizatidine263 X Oral solution Dispense in a light-resistant container
Nortriptyline264 X Capsule (repackaged)
Nystatin265 X Oral suspension
Ofloxacin266 X Tablet, film-coated Dispense in a light-resistant container
Olanzapine267 X Tablet, film-coated
Omeprazole268,269 X X Capsule—Oral powder for suspension
Ondansetron270,271 X X Tablet, film-coated—Tablet, orally disintegrating
Orlistat272 X Capsule
Oxandrolone273 X Tablet Dispense in a light-resistant container
Oxaprozin274 X Tablet Dispense in a light-resistant container
Oxcarbazepine275 X Oral suspension
Oxybutynin276,277 X X Tablet, extended-release—Oral syrup Dispense in a light-resistant container
Oxycodone278,279 X X Capsule—Oral solution
Oxycodone/Acetaminophen280 X X Tablet—Oral solution
Oxycodone/Aspirin281 X Tablet
Oxymetholone282 X Tablet Dispense in a light-resistant container
Pancrelipase283 X Capsule, delayed-release Dispense in original container
Panobinostat284 X Capsule
Pantoprazole285 X Tablet, extended-release Dispense in a light-resistant container
Paregoric286 X Oral liquid Dispense in a light-resistant container
Paroxetine287 X Tablet, film-coated, extended-release
Pentoxifylline288 X Tablet, extended-release
Perphenazine289 X Tablet, film-coated Dispense in a light-resistant container
Phendimetrazine290 X Tablet Dispense in a light-resistant container
Phenobarbital291,292 X X Tablet—Oral liquid
Phenytoin293,294 X X Capsule, extended-release—Oral suspension
Phytonadione295 X Tablet
Pimozide296 X Tablet Dispense in a light-resistant container
Pindolol297 X Tablet
Pioglitazone298 X Tablet
Pitavastatin299 X Tablet, film-coated
Potassium chloride300 X Powder for oral solution
Potassium iodide301 X Oral solution
Pramipexole302 X Tablet
Pravastatin303 X Tablet
Prazosin304 X Capsule
Prednisolone305,306 X X Tablet—Oral solution
Prednisone307 X X Tablet—Oral solution
Primaquine308 X Tablet Dispense in a light-resistant container
Probenecid309 X Tablet, film-coated
Procarbazine310 X Capsule Dispense in a light-resistant container
Prochlorperazine311 X Tablet, film-coated
Progesterone312 X Capsule Dispense in a light-resistant container
Promethazine313,314 X X Tablet—Oral solution
Promethazine/Codeine315 X Oral solution
Promethazine/Phenylephrine316 X Oral solution
Propranolol317 X Oral solution
Propranolol/Hydrochlorothiazide318 X Tablet
Propylthiouracil319 X Tablet
Pyridostigmine320 X Tablet, extended-release
Pyrimethamine321 X Tablet (repackaged)
Quinapril322 X Tablet, film-coated
Quinidine323 X Tablet Dispense in a light-resistant container
Ranitidine324,325 X X Capsule—Tablet, film-coated—Oral solution
Rifampin326 X Capsule
Rilpivirine327 X Tablet, film-coated
Riluzole328 X Tablet
Risperidone329,330 X X Tablet—Tablet, orally disintegrating—Oral solution
Ritonavir331,332 X X Tablet, film-coated—Solution—Powder for oral solution
Ropinirole333 X Tablet
Rosiglitazone334 X Tablet, film-coated Dispense in a light-resistant container
Rosiglitazone/Metformin335 X Tablet, film-coated Dispense in a light-resistant container
Sacrosidase336 X Oral solution
Selegiline337 X Capsule Dispense in a light-resistant container
Sildenafil338 X Tablet, film-coated Dispense in a light-resistant container
Silodosin339 X Capsule
Simethicone340 X Capsule, liquid-filled
Sirolimus341,342 X X Tablet—Oral solution
Sodium polystyrene343 X Powder for oral solution
Sotalol344 X Tablet Dispense in a light-resistant container
Spironolactone345 X Tablet, film-coated
Sulfadiazine346 X Tablet Dispense in a light-resistant container
Sulfamethoxazole/Trimethoprim347,348 X X Tablet—Oral suspension
Sumatriptan349 X Tablet
Suvorexant350 X Tablet, film-coated
Tacrolimus351 X Capsule (repackaged)
Tamoxifen352,353 X X Tablet—Oral liquid
Tasimelteon354 X Capsule
Temazepam355 X Capsule
Terazosin356 X Capsule
Terbinafine357 X Tablet
Terbutaline358 X Tablet Dispense in a light-resistant container
Tetracycline359 X Capsule
Thalidomide360 X Capsule
Theophylline361 X Oral liquid Dispense in a light-resistant container
Thioridazine362 X Tablet, film-coated
Thiothixene363 X Capsule
Thyroid, porcine364 X Tablet
Tiagabine365 X Tablet, film-coated
Timolol366 X Tablet
Tinidazole367 X Tablet
Tolmetin368 X Tablet—Capsule
Tolterodine369 X Capsule, extended-release
Topiramate370 X Capsule, extended-release Dispense in a light-resistant container
Topotecan371 X Capsule
Toremifene372 X Tablet
Trametinib373 X Tablet, film-coated
Tranylcypromine374 X Tablet, film-coated Dispense in a light-resistant container
Trazodone375 X Tablet
Tretinoin376 X Capsule
Triamterene377 X Capsule Dispense in a light-resistant container
Triamterene/Hydrochlorothiazide378 X Capsule
Trimethobenzamide379 X Capsule Dispense in a light-resistant container
Trimethoprim380,381 X X Tablet—Oral solution Dispense in a light-resistant container
Triprolidine382 X Oral syrup Dispense in a light-resistant container
Ursodiol383 X Capsule Dispense in a light-resistant container
Valproic acid384,385 X X Capsule—Oral solution Dispense in a light-resistant container
Vancomycin386 X Powder for oral solution
Verapamil387 X Tablet
Warfarin388 X Tablet
Zafirlukast389 X Tablet, film-coated
Zaleplon390 X Capsule
Zidovudine391,392 X X Tablet, film-coated—Oral syrup Dispense in a light-resistant container
Zileuton393 X Tablet, extended-release
Ziprasidone394 X Capsule Dispense in a light-resistant container
Zolmitriptan395 X Tablet—Tablet, orally disintegrating
Zolpidem396 X Tablet, film-coated, extended-release
Zonisamide397 X Capsule
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a

Additional light sensitivity comments found in the manufacturer’s package insert.

Despite the extensive research done to create this resource, the information provided in Table 1 is only as up-to-date as the date of the resource consulted, and continual reassessment of manufacturers’ recommendations is prudent to ensure changes to storage instructions have not been made.

Footnotes

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.

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