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. 2020 Sep 2;70(10):484–488. doi: 10.1055/a-1236-3041

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This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Fig. 1 — A summary of the probable mechanisms by which proton pump inhibitors (PPIs) could impart therapeutic benefits in COVID-19. While most of the hypothesized mechanisms and in silico findings support their inclusion as potential candidates for repurposing against SARS-CoV-2, clinical evidences do not point towards any benefit unambiguously, denying us from arriving at a definite conclusion.