Table 3.

Health and economic parameters used in the cost-effectiveness analysis

	Parameter	Mean value (95% CI where applicable)	Reference
T	Time horizon	10 years	–
r	Discount rate	3.5%	[7]
Probability of clinical outcomes
rGa	Per-infection probability of GP consultation	0–4 years: 0.006–0.065	[41]
		5–14 years: 0.017–0.018	[44]
		15+ years: 0.014–0.132	[42]
rDa	Per-infection probability of death	0–4 years: 8.197 × 10−6–3.698 × 10−5	[41]
		5–14 years: 6.731 × 10−6–6.896 × 10−6	[44]
		15+ years: 4.663 × 10−6–0.002	[42]
rHa,r	Per-infection probability of hospital admissions	VHR, 0–8 months: 0.133–0.391	[57]
		HR, 0–11 months: 0.013–0.130	[46]
		NR, 0–11 months: 0.010–0.097	[46]
		NR, 1–4 years: 0.004–0.008	[29]
		NR, 5–64 years: 4.688 × 10−5–8.004 × 10−5	[44]
		NR, 65+ years: 6.197 × 10−5–0.019	[42]
rBa,r	Number of hospital bed days per hospitalisation	VHR, 0–8 months: 8–25	[57]
		HR, 0–11 months: 5–7	[46]
		NR, 0–11 months: 1–5	[46]
		NR, 1–64 years: 2	[47]
		NR, 65+ years: 3	[48]
Costs
Per GP visit
ΘGP	All ages	£36.00 (fixed)	[53, 54]
Per hospital bed day
ΘaH	Paediatric (< 5 years of age)	£725.29 (718.13–733.99)1	[56]
ΘaH	Adult (≥ 5 years of age)	£425.24 (415.16–435.70)2	[56]
Administration of prophylactics (per course)
Δpal	Palivizumab	£57.50 (fixed)	[54]
Δmab	La-mABs	£11.00 (fixed)	[54]
Δmat	Maternal vaccine	£9.00 (fixed)	[54]
Δvac	Vaccine	£9.00 (fixed)	[54]
Purchasing prices (per course)
ρpal	Palivizumab	£4035.50 (fixed)	[56]
ρX	La-mABs, Maternal vaccine and vaccine	Not known
QALY loss
Symptomatic infection
QaS	Paediatric (< 5 years of age)	2.336 × 10−3 (0.269 × 10−3–9.255 × 10−3)3	[52]
QaS	Adult (≥5 years of age)	1.448 × 10−3 (0.135 × 10−3–5.928 × 10−3)4	[52]
Hospital admissions
QaH	Paediatric (< 5 years of age)	4.098 × 10−3 (0.624 × 10−3–13.141 × 10−3)5	[52]
QaH	Adult (≥5 years of age)	2.990 × 10−3 (0.346 × 10−3–11.387 × 10−3)6	[52]
Deaths
	Life expectancy	81.0 years	[51]
QaS	Age-specific QALY loss	See Additional file 1: Section 5.2.

Fitted distributions

¹N(725.293, 4.1264

²N(425.242, 5.2781

³Gamma(1.57764, 0.0014807)

⁴Gamma(1.41075, 0.0010264)

⁵Gamma(2.0017, 0.00204726)

⁶Gamma(1.60289, 0.00186539)