Table 1.

The parameters of “Drug-Like Soft” rule

Property	Range	Property	Range
MW	100–600	Rings	≤ 6
logP	− 3 to 6	Max size system ring	≤ 18
HBA	≤ 12	Carbons	3–35
HBD	≤ 7	Hetero atoms	1–15
tPSA	≤ 180	H/C ratio	0.1–1
Rotatable bonds	≤ 11	Charges	≤ 4
Rigid bonds	≤ 30	Total charge	− 4 to 4