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. 2020 Nov 17;12:175. doi: 10.1186/s13148-020-00965-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The level and distribution of hydroxymethylation varies by HPV status. a Global 5hmC distribution pattern over gene bodies in both HPV(+) and HPV(−) samples. b Violin plot of 5hmC logFC in HPV(+) tumors (left) and HPV(−) tumors (right). The number on top indicates the total number of peaks being tested. Wilcoxon signed-rank test p value < 10^–16. c The distribution of hyper-5hmC peaks from HPV(+) and HPV(−) samples, where first column represents the combination of HPV(+) and HPV(−) tumors. The table on the right displayed the p values from Fisher’s exact test between HPV(+) and HPV(−) HNSCC, where exons and introns showed a p value of 10^–12 and 10^–16 respectively