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. 2020 Nov 18;18:438. doi: 10.1186/s12967-020-02616-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Correlations between immune subtypes and immunocytes. a Compositional differences of 22 immunocytes between immune subtype cluster 1 and cluster 2 which was presented by violin-plot (blue means cluster-1 and red means cluster-2). b Comparison of immune-related pathways’ activity between the two immune subtypes. c Comparing periodontitis subtypes, genders, and ages between immune subtype cluster 1 and cluster 2. The heatmap illustrates the association of different clinical characters with cluster 1 and cluster 2 patients. Statistical significance was performed by the χ² test