Figure 8.

Summary of the relevance of the E/I imbalance, neuronal coherence, and NVC. In control mice, synaptic excitatory and inhibitory transmission is well balanced, inducing highly coherent activity between excitatory and inhibitory neurons. However, increases in glucocorticoid levels induced by a single acute stressor induces a decreasing trend in the amplitude of sEPSCs and an increasing trend in the amplitude of sIPSCs, leading to a reduction in the E/I ratio. Disruption of the E/I balance is accompanied by undermined neuronal coherence, and the positive relationship between the strength of neuronal coherence and the time to peak of the penetrating arteriolar response is completely abolished by acute stress.