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. 2020 Nov 17;11:5828. doi: 10.1038/s41467-020-19651-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Synthesis of PEO-b-P(MAC-SR·HCl) (abbreviated as PSR) by ring-opening polymerization and thiol-ene reactions. The final copolymers consist of a hydrophilic PEO segment (blue), a degradable polycarbonate backbone (green), and ionizable tertiary amines lending pH sensitivity (red). b dUPS polymers display ultra-pH sensitivity and strong buffer capacity at their relative pK_a. PSDMA titration is presented separately in Supplementary Fig. 10. c pK_a values are inversely correlated with the log P of the repeating unit of the P(MAC-SR) segment (neutral/deprotonated state). d Number-weighted hydrodynamic diameters and light scattering count rates as a function of protonation degree during the PSC7A titration. CMPD: critical micellization protonation degree. e TEM images and corresponding number-weighted hydrodynamic diameter distributions by dynamic light scattering (DLS) analysis of PSC7A in 150 mM NaCl solution at 95% and 85% protonation degrees, above and below CMPD. Scale bar: 100 nm. TEM measurements of PSC7A polymer solutions at 85% and 95% protonation degrees were repeated three times independently with similar results, and one representative image from each group was shown.