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. 2020 Nov 17;11:5828. doi: 10.1038/s41467-020-19651-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a C57BL/6 healthy mice were treated with PBS, E7p, PSC7A NP, and PC7A vaccine (PC7A vax.) or PSC7A vaccine (PSC7A vax.) three times in 6 day intervals. One day after the last administration (on day 13), the mice were sacrificed and lymph nodes were harvested for flow cytometry analysis. b Summary of percentage of CD80⁺ DCs in inguinal lymph nodes 1 day after the last administration. n = 6 biologically independent mouse samples in each PBS and E7p group. n = 7 biologically independent mouse samples in each PSC7A NP, PC7A vaccine, and PSC7A vaccine group. Data are presented as means ± s.e.m. and statistical significance was calculated using Student’s two-tailed t-test (PSC7A vax. vs. E7p: ^***P = 0.0008, PSC7A vax. vs. PSC7A NP: ^****P < 0.0001, PSC7A vax. vs. PBS: ^****P < 0.0001). c Representative flow dot plots of E7 tetramer staining of CD8⁺ T cells in lymph nodes and summary of percentage of E7 tetramer⁺ CD8⁺ T cells measured by flow cytometry. n = 6 biologically independent mouse samples in each PBS and E7p group. n = 7 biologically independent mouse samples in each PSC7A NP, PC7A vaccine, and PSC7A vaccine group. Data are presented as means ± s.e.m. and statistical significance was calculated using Student’s two-tailed t test (PSC7A vax. vs. E7p: ^****P < 0.0001, PSC7A vax. vs. PSC7A NP: ^****P < 0.0001, PSC7A vax. vs. PBS: ^****P < 0.0001).