Skip to main content
. 2020 Nov 17;11:5828. doi: 10.1038/s41467-020-19651-7

Fig. 6. Short-term safety evaluation of degradable PSC7A NP and non-degradable PC7A NP.

Fig. 6

a C57BL/6 mice were subcutaneously injected with PBS, 300 μg PSC7A NP, or 300 μg PC7A NP on the right flank. b Serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine levels were quantitatively measured by AbcamTM Assay Kit 24 h after injection. n = 4 biologically independent mouse samples in each group. Data are presented as means ± s.e.m. c Serum concentrations of interleukin-6 (IL-6), interleukin-10 (IL-10), monocyte chemoattractant protein-1 (MCP-1), interferon-γ (IFN-γ), tumor necrosis factor (TNF), and interleukin-12p70 (IL-12p70) protein levels were quantitatively measured by BDTM CBA Mouse Inflammation Kit 24 h after injection. n = 4 biologically independent mouse samples in each group. Data are presented as means ± s.e.m. and statistical significance was calculated using Student’s two-tailed t test (****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05) and the exact P values are indicated in the figures.