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. 2020 Nov 17;10:19981. doi: 10.1038/s41598-020-75855-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The network of protein–protein interactions (PPI) constructed for differentially expressed genes (found in all analyses) using the STRING online database¹⁵¹ (see “Methods” section and Supplementary Figs. S1–S3 for details). Genes represented as numbers refer to “ENSDARG000000*”, where * denotes the last 5 digits of the Ensembl gene names (ID). The network was visualized using the CytoScape application^149,150. SvC stress vs. control, FvC fluoxetine vs. stress, SFvC differentially expressed in both SvC and FvC (in same l2fc direction), FvS fluoxetine vs. stress, SvCF differentially expressed in SvC and FvS (in opposite directions, color refers to the direction of FvS expression change), Additional—20 proteins with the highest interaction score in STRING for suggested PPI networks. Letters denote several clusters of genes, including (A) arrestins and G protein-coupled receptors (GPCRs) related genes, (B) ubiquitin-related genes and their inflammatory modulators, (C) inflammation-related transcription factors, (D) cytoskeletal and motility related proteins, (E) vitellogenins.