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. 2020 Nov 17;10:19981. doi: 10.1038/s41598-020-75855-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene co-expression (GE) network constructed for differentially expressed genes (found in all analyses) using the GeneMANIA^155–158 online database (see the “Methods” section, and Supplementary Figs. S1–S3 for details of treatment and network construction). The network was graphically presented using the CytoScape application^149,150. SvC stress vs. control, FvC fluoxetine vs. stress, SFvC differentially expressed in both SvC and FvC (in same l2fc direction), FvS fluoxetine vs. stress, SvCF differentially expressed in both SvC and FvS (in the opposite direction, color refers to the direction of FvS expression change), Additional—20 genes with the highest co-expression score in GeneMANIA for suggested PPI networks. (A) fluoxetine vs. stress-related genes that are commonly co-expressed.