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. 2020 Nov 17;11:5840. doi: 10.1038/s41467-020-19548-5

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© The Author(s) 2020

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Fig. 8 — Left panel: Without NAC, the ribosome dominates the interactions of SRP, and even RNCs with a weak signal sequence (red zigzag line) or with a short nascent chain can induce SRP to dynamically sample the proximal conformation that rapidly associates with SR at the ER. Right panel: NAC (purple) co-binds with SRP to a variety of RNCs and selectively drives SRPs into inactive conformations on RNCs with a weak signal sequence or a short nascent chain, thus inhibiting the ER localization of ribosomes without an exposed and functional signal sequence.