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. 2020 Nov 17;11:5847. doi: 10.1038/s41467-020-19554-7

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

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Fig. 2 — Wild-type (Ppara^+/+) mice were treated with WY-14643 and stranded RNA-seq was performed on total liver mRNA. a Expression of the antisense lncRNA Gm15441 is strongly upregulated. b Expression of the protein-coding Txnip mRNA is downregulated. Shown are the changes in expression of Gm15441 (c), and Txnip (d), mRNAs in Ppara^+/+ and Ppara^−/− mice treated with WY-14643, or vehicle control, for 48 h, determined by qRT-PCR. e Time course for changes in expression of Gm15441 and Txnip mRNA over a 24 h period following treatment with WY-14643 by gavage, determined by qRT-PCR. The maximum response of Txnip mRNA was seen at 1.5 h and for Gm15441 was seen at 6 h. Each data point represents the mean ± SD for n = 5 liver samples. Adjusted p values, provided in the panels, as determined by ANOVA with Tukey’s multiple comparison correction, two-sided for comparisons to Ppara^+/+ mice or as shown (dashed horizontal line).