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. 2020 Nov 17;3:682. doi: 10.1038/s42003-020-01408-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–l M-mode echocardiography was used to evaluate cardiac functional parameters in mice treated with vehicle (saline) (n = 5) and METH (n = 6) 4 weeks after the subcutaneous administration of vehicle or METH. METH treatment causes a significant decline in M-mode echocardiography parameters, including c percent fractional shortening (%FS) and f percent ejection fraction (%EF) compared with those in the vehicle-treated mice. a–l Bar graph represents a left ventricular (LV) systolic internal dimension (LVID;s); b LV diastolic internal dimension (LVID;d); c percent fractional shortening (%FS); d LV systolic volume (LV Vol;s); e LV diastolic volume (LV Vol;d); f percent ejection fraction (%EF); g heart rate (beats/minute); h LV systolic interventricular septum thickness (IVS;s); i LV diastolic interventricular septum thickness (IVS;d); j LV systolic posterior wall thickness (LVPW;s); k LV diastolic posterior wall thickness (LVPW;d); I LV mass in vehicle- (n = 5) and METH- (n = 6) treated mice. Boxes depict interquartile ranges, lines represent medians, and whiskers represent ranges. A two-tailed unpaired Student’s t test was used to determine P values. P < 0.05 between groups was considered statistically significant. NS not significant, Veh vehicle, METH methamphetamine.