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. 2020 Oct 15;20(6):230. doi: 10.3892/etm.2020.9360

Figure 1.

Figure 1

Effects of uc.48+ siRNA on the nociceptive behavior of type 2 diabetic mice. The behavior of the mice was assessed using MWT (upper panel) and TWL (lower panel) assays. At 6W, no significant differences in MWT were detected among the four groups, while the TWLs of the DM, DM + NCsi and DM + uc.48+ si groups were lower than that of the control group. At 7W, the MWTs and TWLs of the DM, DM + NCsi and DM + uc.48+ si groups were lower compared with those of the control group. At 8W, the MWT and TWL of the DM + uc.48+ si group were higher than those of the DM and DM + NCsi groups. n=6/group. *P<0.05, **P<0.01 vs. the control group; #P<0.05, ##P<0.01 vs. the DM group. siRNA, small interfering RNA; uc.48+ si, uc.48+ siRNA; NCsi, scrambled control siRNA; MWT, mechanical withdrawal threshold; TWL, thermal withdrawal latency; 6W, 6 weeks (prior to STZ injection); 7W, 7 weeks (following STZ injection); 8W, 8 weeks (after siRNA injection); DM, diabetes mellitus; STZ, streptozotocin.