Table 1.

Patient demographics and surgical factors by PBD.

		PBD
	N	No (n=73)	Yes (n=84)	p-Value
Patient Demographics
Age at MDT Assessment (Years)	157	66.2 ± 8.7	68.9 ± 9.7	0.075
Gender (% Male)	157	36 (49%)	47 (56%)	0.427
BMI	152	26.7 ± 4.9	27.4 ± 5.5	0.152
CCI	157			0.199*
2-3		14 (19%)	15 (18%)
4-5		41 (56%)	38 (45%)
6+		18 (25%)	31 (37%)
Smoking Status	157			0.286
No		60 (82%)	71 (85%)
Current		10 (14%)	6 (7%)
Ex		3 (4%)	7 (8%)
CA19-9 (U/ml)	135	307 (116–959)	318 (92–1718)	0.643
Surgery	157	73 (100%)	61 (73%)	<0.001
Surgical Factors
Days from Diagnosis to Surgery**	134	14 (10–21)	59 (45–77)	<0.001
Bilirubin (at Surgery, µmol/L)**	133	307 (222–411)	15 (8–61)	<0.001
Type of Surgery**	134			<0.001
Resection		71 (97%)	45 (74%)
Bypass		2 (3%)	16 (26%)
Vein Reconstruction***	116	20 (28%)	8 (18%)	0.292
T-Stage***	116			0.496*
T1		13 (18%)	9 (20%)
T2		55 (77%)	30 (67%)
T3		3 (4%)	6 (13%)
N-Stage***	116			0.547*
N0		9 (13%)	4 (9%)
N1		32 (45%)	20 (44%)
N2		30 (42%)	21 (47%)
Overall Stage***	116			0.468*
1		8 (11%)	3 (7%)
2		32 (45%)	20 (44%)
3		31 (44%)	22 (49%)
R-Status (% R1)***	116	29 (41%)	17 (38%)	0.846
LN ratio***	116	0.19 (0.07–0.36)	0.21 (0.06–0.33)	0.966

Patient demographics are reported for the cohort as a whole, while surgical factors are reported only for the subgroup who underwent surgery (N=73/61 for PBD No/Yes), and tumor staging and resection-related factors for the subgroup that underwent resection (N=71/45). Continuous data are reported as mean ± SD, or as median (interquartile range), with p-values from Mann-Whitney U tests. Categorical data are reported as N (%), with p-values from Fisher’s exact tests or Chi-square. Bold p-values are significant at p<0.05. *p-Value from a Mann-Whitney U test, as the factor is ordinal. **In patients undergoing surgery; time is from initial CT scan. ***In patients undergoing resection.

MDT, multidisciplinary team; BMI, body mass index; CCI, Charlson Comorbidity Index; LN ratio, lymph node ratio.